How Safe Is CBD? Exploring Its Safety Profile Through A Recent Study

As the popularity of Cannabidiol (CBD), a naturally occurring compound extracted from the hemp plant, grows, so do questions about safety, particularly around dosage. A recent randomized controlled trial published in JAMA Internal Medicine in September 2025 and available through the National Library of Medicine offers valuable insights into how CBD affects the body, even at unusually high doses.

This study specifically examined whether sustained high doses of CBD could impact liver enzyme levels. Liver enzymes are markers used in blood tests to assess liver function. When these levels rise, it can indicate that the liver is under stress or working harder than usual. In more serious cases, sustained elevations can point to inflammation or injury. However, context matters: temporary or mild increases do not necessarily indicate damage, especially if they resolve on their own.

Quick Recap: How CBD Work

Before looking at the study’s findings, it helps to understand how CBD interacts with our bodies. CBD works through the endocannabinoid system (ECS), a network of receptors that helps regulate processes such as mood, pain perception, sleep, and immune response. Unlike some substances that act by strongly activating or blocking receptors in the body or the brain, CBD works indirectly by modulating receptor activity and enzyme function to help the body maintain balance (homeostasis). This regulatory approach is why CBD is often described as well-tolerated and associated with a broad range of potential benefits.

CBD and Liver Health

Concerns about CBD and liver health have largely stemmed from earlier animal studies. In some of these studies, particularly those involving mice, extremely high doses of CBD (in ratios far beyond what any human would ever consume) were associated with elevated liver enzymes (leading to acute or sub-acute toxicity). These doses were often administered in concentrated, acute forms. These studies are important for identifying safety thresholds, but they do not reflect how CBD is typically used. As with many compounds, including water, excessive intake can lead to unintended effects, highlighting the importance of context and dosage.

Understanding the Study’s Findings

The 2025 human trial addressed this gap. Participants were given a high daily dose of CBD, approximately 5 mg per kilogram of body weight, for 28 days. For an average adult, this represents a substantial intake, significantly higher than standard consumer use and what Hemp for Health by Jammin Canna founder, Garth O. Vaz, MD, recommends to patients and customers. Even under these conditions, only about 5–6% of participants showed elevated liver enzyme levels after 28 days. Most importantly, no liver damage was observed, and enzyme levels in those individuals returned to normal within one to two weeks after discontinuing CBD.

These findings reinforce a key point: CBD demonstrates a strong safety profile, even when used at levels well above typical daily intake. The small percentage of temporary enzyme elevations, without lasting effects, suggests that the body can process CBD effectively in most cases. It also highlights the importance of dosage awareness, particularly for individuals using higher amounts over extended periods.

For everyday use, CBD does not need to be consumed in large quantities to be effective. Because it interacts with the endocannabinoid system its effects are often achieved at moderate, consistent doses. More is not necessarily better, and excessive intake does not enhance outcomes in a proportional way. When in doubt, Dr. Vaz recommends following the suggested dosage as indicated on the product packaging of trustworthy and well-established brands, including Hemp for Health’s own product line. For individuals with underlying health conditions or those taking other medications, consulting a healthcare professional before trying CBD remains a prudent step.

As new research continues to emerge, we look forward to keeping our readers informed, sharing insights on CBD’s safety, the evolving science of cannabinoids, and their potential role in supporting human health today and into the future.